Carville produced the world’s first diffusion bonded medical manifold for an IVD blood diagnostics application in 1980.
Medical ManifoldCarville produced the world’s first diffusion bonded medical manifold for an IVD blood diagnostics application in 1980.
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Plastic medical manifolds or Medical fluidic manifolds
Gas & Fluid Medical ManifoldPlastic medical manifolds or Medical fluidic manifolds
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Diffusion bonded medical manifold with stainless steel pin capillaries. The pins are secured in place with external cemented joints allowing tubing to connect to the manifold.
Medical ManifoldsDiffusion bonded medical manifold with stainless steel pin capillaries. The pins are secured in place with external cemented joints allowing tubing to connect to the manifold.
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A diffusion bonded manifold for use in medical blood analysis. This medical manifold has been enhanced by the incorporation of valves and peristaltic pumps. The pumps are securely fastened to the manifold by the use of threaded brass inserts.
Medical ManifoldsA diffusion bonded manifold for use in medical blood analysis. This medical manifold has been enhanced by the incorporation of valves and peristaltic pumps. The pumps are securely fastened to the manifold by the use of threaded brass inserts.
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Complex medical manifolds can be produced with smaller channel sizes for use in hand held point of care devices.
Medical ManifoldsComplex medical manifolds can be produced with smaller channel sizes for use in hand held point of care devices.
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This manifold is produced in clear and opal (white) cast acrylic. The medical manifold has been produced with tracks that ensure a precise fluid volume between the inlet and outlet ports. Inlet and outlet interconnects are made by means of stainless steel capillary pins.
Plastic Medical ManifoldThis manifold is produced in clear and opal (white) cast acrylic. The medical manifold has been produced with tracks that ensure a precise fluid volume between the inlet and outlet ports. Inlet and outlet interconnects are made by means of stainless steel capillary pins.
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Micro fluidic medical manifolds can be manufactured with track sizes down to 150 uM. These smaller medical manifolds are typically used in disposable applications.
Medical ManifoldsMicro fluidic medical manifolds can be manufactured with track sizes down to 150 uM. These smaller medical manifolds are typically used in disposable applications.
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A large medical manifold used to process 12 samples simultaneously within a medical diagnostics machine. This medical manifold is multi-layered and has been CNC machined and diffusion bonded using cast clear plastic acrylic.
Medical ManifoldA large medical manifold used to process 12 samples simultaneously within a medical diagnostics machine. This medical manifold is multi-layered and has been CNC machined and diffusion bonded using cast clear plastic acrylic.
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Not all medical manifolds are bonded. This small medical fluidic device has been precision CNC diamond machined in cast acrylic and interfaces with other external component parts.
Medical ManifoldNot all medical manifolds are bonded. This small medical fluidic device has been precision CNC diamond machined in cast acrylic and interfaces with other external component parts.
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Manifolds can have several layers and feature tracks in 3 axis. This Complex 7-layer diffusion bonded medical manifold measures 200mm x 150mm x 30mm and offers 64 inlet and outlet ports.
Medical manifoldManifolds can have several layers and feature tracks in 3 axis. This Complex 7-layer diffusion bonded medical manifold measures 200mm x 150mm x 30mm and offers 64 inlet and outlet ports.
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A large 3 layer valve manifold used in a medical application. This medical manifold features machined diaphragms and is produced in clear and opal (white) acrylic.
Clear and Opal Acrylic ManifoldA large 3 layer valve manifold used in a medical application. This medical manifold features machined diaphragms and is produced in clear and opal (white) acrylic.
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This acrylic medical manifold uses plastic capillaries and encompasses sensors and control electronics.
Medical ManifoldThis acrylic medical manifold uses plastic capillaries and encompasses sensors and control electronics.
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This large 3 layer cast acrylic medical manifold forms part of the chassis in a medical machine. The medical manifold is populated with control valves and connectors and is used for DNA sequencing and profiling.
Medical ManifoldThis large 3 layer cast acrylic medical manifold forms part of the chassis in a medical machine. The medical manifold is populated with control valves and connectors and is used for DNA sequencing and profiling.
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Small channel medical manifolds are used in the development and testing of new drugs within the pharmaceutical industry.
Medical ManifoldsSmall channel medical manifolds are used in the development and testing of new drugs within the pharmaceutical industry.
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Polysulphone (PSU) is ideally suited for medical manifold components when it is necessary to clean using autoclave techniques. The image shows a slide used in DNA profiling.
Medical ManifoldPolysulphone (PSU) is ideally suited for medical manifold components when it is necessary to clean using autoclave techniques. The image shows a slide used in DNA profiling.
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This image shows a 3-layer diffusion bonded medical manifold produced in cast clear acrylic. The medical manifold is used in an IVD medical application.
Medical ManifoldThis image shows a 3-layer diffusion bonded medical manifold produced in cast clear acrylic. The medical manifold is used in an IVD medical application.
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    Medical Manifolds

     

    What is a Medical Manifold?

    Medical Manifolds

    A medical manifold is a means of bringing together multiple samples (gas, fluid, oxygen etc) in a simple, repeatable and reliable manner. Medical manifolds may be injection moulded low cost disposables or larger more complex components produced using CNC machining and bonding techniques.

    Diffusion Bonded medical manifolds have become a standard in the medical industry. They are typically used to handle and process fluid, gas, oxygen, reagents and samples within clinical diagnostics, point of care, laboratory equipment and drug development applications.

     

    When were the first Medical Manifolds produced?
    Carville developed a diffusion bonding technique to bond acrylic materials for use in aerospace applications in the 1960’s. Diffusion bonding allows acrylic materials to be bonded without the use of solvents or adhesives.

    In 1980, Carville entered in to a development programme with Corning Medical. Corning Medical was designing and manufacturing blood diagnostic equipment and wanted to find a more reliable way to process samples and reagents.

    Carville worked with Corning Medical and used our diffusion bonding techniques to develop the worlds first diffusion bonded medical manifold. This first medical manifold was a simple two layer components and was used for a blood diagnostics application.

     

    How are Medical Manifolds manufactured?
    Medical Manifolds are produced from fully heat treated cast clear acrylic. The acrylic material is diamond machined to achieve plates which are flat and parallel before adding the required internal track features and then bonding the plates together.

    As medical manifolds are machined and bonded, they offer the design engineer the ability to introduce smooth flow baths and complex internal features which can not be achieved using conventional machining or moulding techniques. Internal tracks can be machined at various widths to create restrictions or reservoirs when it is necessary to build up a buffer of samples or reagent.

     

    Is it possible to add components to a Medical Manifold?
    The function of medical manifolds can be enhanced with a number of additional components such as peristaltic pumps, flow control valves, solenoids, heater modules, electrical circuitry and filters. Carville have produced simple manifolds requiring a few valve to much larger assemblies requiring 300 valves.

     

    How are samples or Reagents introduced to a Medical Manifold?
    Carville can produce medical manifolds with a range of standard or bespoke fittings. Customers will typically use either threaded fittings in plastic or press fit stainless steel capillaries.

     

    Why do Medical Companies use Manifolds?
    Medical Manifolds are produced using CNC manufacturing techniques and offer a repeatable and reliable component which removes the requirement for tubing and multiple connections. Removing the tubing and connections from a Medical Manifold will offer cost savings in product manufacture and assembly.

    Medical Manifolds are bespoke components unique to each application. Removal of multiple tubes and connections will reduce dead volumes within equipment and improve sample flow during sample processing. It is possible to have smooth flowing tracks inside the manifold rather than sharp corners with 90⁰ bends. This will improve the performance of the diagnostic equipment.

    As manifolds are transparent, it is possible to view samples in process. It is also possible to view the manifold cleaning cycle to ensure that the manifold is clean between tests. This reduces the risk of cross contamination in sampling and testing.

    Another benefit of a transparent manifold is the option to fit optical devices to perform cell counting and other tests within the assembly. This is common practice in blood diagnostics.

    When it comes to servicing, switching a manifold as part of a preventative maintenance programme is easier and more reliable than the removal and replacement of individual valves and tubes. A Medical Manifold allows servicing to be completed more efficiently and reduces the risk of errors by service personnel.

     

    How many Manifolds have Carville produced?
    Carville produced the first medical manifold in 1980 and supply to customer in Europe, Asia and the USA. Carville have manufactured in excess of 1,000,000 manifolds in materials ranging from Acrylic (PMMA) to Ultem (PEI).

     

    How do we get a quotation for a Medical Manifold?
    Customers should submit 2D drawings (.dwg or .pdf) along with a 3D model (.stp) for Carville to review. These files, along with the required quantities, should be sent to sales@carville.co.uk

    Carville will offer feedback on the suitability of the manifold for manufacture along with suggestion to improve manifold performance and reduce manufacturing costs.

     

    Where can we see samples of Manifolds produced by Carville?
    Examples of plastic medical manifolds produced by Carville can be reviewed at the top of this page and in the Carville image library.

     

    Summary of Benefits
    There are many attractive properties that encourage medical companies to adopt, design and use acrylic manifolds. These include:

    –      Ease of assembly.
    –      Reduced cost of assembly.
    –      Improved reliability.
    –      Reduction in dead volumes.
    –      Improved diagnostic performance.
    –      Visualisation of system operation.
    –      Ease of maintenance.