Carville started to manufacture micro fuidic devices and chips for drug development and point of care testing in 2000. We have worked with a range of companies from high tech start ups to global multinationals suppling early prototypes through to higher volume production quantities. Products include disposable diagnostic chips, lab on a chip, equipment manifolds and flow reducers. Applications range from clinical chemistry, biotech, point of care devices and a broad range of In Vitro Diagnostics systems.
Micro Fluidic Materials
The micro fluidic devices manufactured by Carville are produced in a range of materials including Acrylic/Plexiglas (PMMA), Polycarbonate (PC), Polysulphone (PSU), Polyetherimide (PEI, Ultem) and Cyclic Olefin Copolymer (COC). For High Accuracy Diffusion Bonded (HADB) micro fluidic manifolds, we gernally use PMMA or Ultem for more aggressive chemicals or higher temperatures.
Micro Fluid Production
The internal features of the micro fluidic device are CNC machined so prototype and small qualities can be produced without the need for expensive mould tooling. Micro fluidic devices can contain a number of features such as small tracks, mixing cells and optical windows for sample analysis. Carville currently produce plastic micro fluidic chips with small track widths down to 150 microns (0.006”). Using Carville’s unique High Accuracy Diffusion Bonding (HADB) we can produce either single or multi-layer micro fluidic manifolds to very tight tolerances in a highly repeatable production method. We can also machine and polish external layers post bonding to be a thin as 200 microns if required which allows clear optical imaging for sample analysis equipment.
Prototyping Micro Fluidics
Carville support a number of clients in the early stages of design and validation with prototype quantities of CNC machined microfluidic chips whilst they experiment with design options. This gives them a cost effective and flexible way to optimise and freeze the design prior to investing in expensive injection moulding tooling if that is the manufacturing route they wish to take.